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ASCP MEDICAL LABORATORY TECHNICIAN - MLT(ASCP) Sample Questions:

1. Coumarin derivatives inhibit the vitamin K dependent Factors (II, VII, X) which can be measured with the PT and monitored frequently with the INR assay.
Hematology
Warfarin-based (coumarin derivative) oral anti-coagulant therapy is commonly monitored with :

A) PT/INR
B) APTT
C) APTT and PT
D) Thrombin time

2. According to the Michaelis-Menton kinetics theory, when a reaction is performed in zero-order kinetics:

A) The substrate concentration is very low and the reaction rate is dependent on the substrate concentration
B) The substrate concentration is in excess and the reaction rate is dependent on the enzyme concentration
C) The enzyme concentration is in excess and the reaction rate is dependent on the substrate concentration
D) The substrate concentration is equal to Km and the reaction rate is dependent on the enzyme concentration

3. Troponin is potentially more specific for myocardial damage than CK-MB and stays elevated longer. It may eventually replace CK-MB as the standard marker of myocardial damage. In addition, troponin T has been known to be elevated in the setting of even mild degrees of renal failure. Troponin and CK-MB both tend to rise approximately 3 hours after a MI (hence why the correct answer is "A", since it is false); however, troponins can stay elevated up to 2 weeks as CK-MB tends to return to baseline around 36 hours.
Chemistry
Which of the following statements is FALSE regarding troponin?

A) It rises much sooner after an MI than CK-MB
B) Troponin T is often elevated in renal failure patients
C) It stays positive much longer than CK-MB
D) It is potentially more specific than CK-MB

4. What two glycoproteins are expressed on the surface of influenza A viruses and are used for subtyping of the viruses?

A) Hemagglutinin
B) Glycoprotein120 (gp120)
C) Neuraminidase
D) Glycoprotein41 (gp41)

5. Either immunofixation or immunoelectrophoresis can be used to confirm Bence-Jones proteinuria.
Which of the following methods would be used to confirm the presence of Bence-Jones protein in the urine:

A) Isoelectric focusing
B) Immunofixation
C) Sulfosalicylic acid
D) Urine protein electrophoresis

Solutions: