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BPS Pharmacotherapy (Part1 and Part2) Sample Questions:

1. A 50-year-old woman experienced acute renal failure after receiving contrast dye for an imaging study. Her estimated creatinine clearance is now 20 mL/min. Her medications include:
* Piperacillin/tazobactam 4.5g intravenously every 8 hours
* Azithromycin 500 mg intravenously daily
* Famotidine 40 mg orally twice daily
* Enoxaparin 40 mg subcutaneously daily
* Metoprolol succinate 100 mg orally daily
Which drugs require dose reduction due to acute renal failure?

A) All of her current medications
B) Piperacillin/tazobactam, famotidine, and metoprolol succinate
C) Piperacillin/tazobactam, azithromycin, and enoxaparin
D) Piperacillin/tazobactam, famotidine, and enoxaparin

2. A pharmacotherapy specialist is contemplating Writing a case report on a suspected penicillin induced neutropenia in a patient who received intravenous penicillin G for treatment of infective endocarditis. The specialist has established a temporal relationship between the period of medication administration and the onset of neutropenia, and has excluded other potential causes of the adverse effect.
Which of the following is the most appropriate next step in composing the case report?

A) Generate ideas and wording for the patient case summary portion of the report.
B) Collect all pertinent patient information, including past medical history, laboratory data, medication history, and consent.
C) Describe the incidence, severity, and outcome of penicillin-induced neutropenia for the introduction section of the report.
D) Perform a comprehensive literature search to identify existing literature describing neutropenia in penicillin-treated patients.

3. A MEDLINE search fails to retrieve a clinical trial known by the searcher to have been published in a recently established open-access medical journal. This failure has most likely occurred because of which of the following?

A) The time that the journal has been available does not meet criteria for indexing.
B) MEDLINE does not index open-access journals.
C) MEDLINE selectively indexes articles of the highest scientific merit.
D) The searcher limited the search to "humans" and "English language."

4. A 35-year-old Woman is diagnosed with pustular psoriasis, which covers 35% of her body. She has tried high-potency topical steroid creams and topical coal tar with ultraviolet B treatments in the past, with no effect. Which of the following is the best therapeutic option for this patient?

A) Calcipotriene
B) Halobetasol
C) Methotrexate
D) Anthralin

5. A 45-year-old patient develops neutropenia, fever, headache, meningismus, and lethargy after induction chemotherapy for acute lymphocytic leukemia. A lumbar puncture reveals 1,000 total nucleated cells with elevated CSF protein with gram stain showing Gram-positive rods. Which of the following is the best initial empiric therapy for this patient?

A) Ceftazidime and gentamicin
B) Ampicillin
C) Ampicillin and cefotaxime
D) Ceftriaxone

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